Detection of neurodegeneration and amyloid plaques in the mouse brain of a model for Alzeimer¡¦s disease. 40 £gm cryostat section was cut coronally through the dorsal hippocampus of a transgenic mouse used as a model for studing Alzeimer¡¦s disease. The section was processed for detecting both neuronal damage and amyloid plaques with NDT 103 Kit. Note silver-stained plaques in both the hippocampus and the cortex (click to see enlarged photo).
High mignification of the hippocampal CA1 area as shown above. Note that in addition to silver-stained amyloid plaques, numerous degenerating fibers are also present in the corpus callosum (click to see enlarged photo).