Detection
of neurodegeneration
and amyloid plaques
in the mouse brain
of a model for Alzeimer¡¦s
disease.
40 £gm cryostat section
was cut coronally
through the dorsal
hippocampus of a
transgenic mouse
used as a model
for studing Alzeimer¡¦s
disease. The section
was processed for
detecting both neuronal
damage and amyloid
plaques with NDT
103 Kit. Note silver-stained
plaques in both
the hippocampus
and the cortex (click
to see enlarged
photo).
High
mignification of
the hippocampal
CA1 area as shown
above. Note
that in addition
to silver-stained
amyloid plaques,
numerous degenerating
fibers are also
present in the corpus
callosum
(click to see enlarged
photo).
