Detection
of neurodegeneration
with NeuroSilver
Kit (NDT103). A:
Section (40
£gm) through the
dentate gyrus of
the hippocampus
from a rat injected
with kainic acid
(10 mg/kg, s.c.),
showing degenerating
neurons and processes
(black) in the polymorphic
layer (pl) and the
molecular layer
(ml), respectively.
B:
Coronal section
(30 £gm) through
the septum of a
rat, killed at 10
days following a
unilateral transection
of the fimbria.
Note degenerating
axons (indicated
by the arrow) in
the ipsilateral
fornix.
C: Horizontal
section (40 £gm)
through the hippocampal
dentate gyrus of
a rat killed at
5 days after the
intra-entorhinal
injection with aminooxyacetic
acid. Note numerous
degenerating axon
terminals (arrowheads)
in the middle zone
of the molecular
layer (ml), the
terminal field of
entorhinal neurons
killed by the drug
injection (for details,
cf. Neuroscience
82:1165, 1998).
D:
Coronal section
(40 £gm) through
the lateral geniculate
nucleus of a rat
killed at 5 days
after a unilateral
visual cortex aspiration.
Note dense degenerating
axon terminals in
the subgeniculate
nucleus (SubG) (Section
courtesy of Dr.
E.-Y. Chen, Rush
University [D])
(click
to see enlarged
photo).
Detection
of neurodegeneration
in the rat brain
of a stroke model.
40 £gm cryostat
section was cut
coronally through
the striatum of
a rat used as an
animal model of
stroke. The section
was processed for
demonstrating neuronal
damage with NDT103
Kit. Note the accumulation
of metallic silver
grains (black) in
both the striatum
and the cortex,
indicating the presence
of neurodegeneration
(click
to see enlarged
photo).
Detection
of neurodegeneration
in the rat brain
of an epilepsy
model.
40 £gm cryostat
section through
the cortex of
a rat used as
an animal model
of epilepsy. Note
degenerating neurons
(black) in the
deep layers
(click to see
enlarged photo).
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